Dow
Jones
8277.15
+36.77
1:30
pm PST, April 4, 2003
NASDAQ
1383.51
-13.07
For
info, visit access.smallcapnetwork.com
S
& P 500
878.85
+2.40
To
be removed, please click
here
Russell
2000
373.28
-1.94
VOLUME
03: ISSUE 12
CEL-SCI
--The Quest for Immunization against Bio-Terrorism
Lots of exciting developments at
biotech firm CEL-SCI Corp (CVM:
AMEX), both in product development and research funding.
CEL-SCI Corp's development of its
CEL-1000 compound as a possible drug/vaccine against multiple bio-terrorism
agents took a significant step forward with today's announcement of the
receipt of a $1.1 million US. Government grant.
In an environment where it is extremely
difficult to secure funds, this significant infusion recently awarded speaks
to the importance and relevance of CEL-SCI's work. Shareholders--both new
and potential --would be wise to take note of this impressive corporate
funding achievement.
CEL-SCI secured the grant with partner
Northeastern Ohio Universities College of Medicine (NEOUCOM), after a peer
review process, to further its pre-clinical work leading to toxicology
studies on CEL-1000 as a treatment for viral encephalitis-a potentially
lethal inflammation of the brain.
"Results from recent work in different
infectious diseases suggest that CEL-1000 operates through the enhancement
of the first line human immune defense mechanism (innate immunity) to prevent/fight
disease. These findings make CEL-1000 a prime candidate for bio-defense
applications, both as a preventive vaccine and treatment," said Daniel
Zimmerman, Senior Vice President of Research, Cellular Immunology of CEL-SCI,
earlier this year.
A Broad Spectrum Application for
Investors
CEL-SCI's work with CEL-1000 as a
treatment for encephalitis also has application to a myriad of causes for
the disease, which could prove timely given the national concern about
the potential for bio-terrorism attacks. A list of these causes include
the Herpes Simplex Virus (type 1 and 2) the West Nile virus, as well as
three viruses identified by the Federal Government as having the second
highest risk as biological weapons-specifically the Venezuelan, Eastern
and Western Equine Encephalitis viruses.
CEL-1000 continues CEL-SCI's tradition
of developing immune enhancing drug/therapies, such as its immune stimulant
Multikine --which the company hopes to receive FDA approval later this
year to begin Phase III trials. While Multikine is targeted at head and
neck cancers, the company is confident that once the clinical data on the
drug's efficacy is available from a Phase III trial, it will offer treatment
for many types of this deadly affliction. Unlike big Pharma companies,
CEL-SCI's mandate is to develop immune enhancing therapies and drugs for
the early detection and treatment of disease.
CEL-SCI CEO Geert Kersten states
that the company will apply all grant funds to the development of bio-terrorism
products as well as other non-Multikine projects. Further, CEL-SCI Officers,
Directors and employees recently purchased nearly 800,000 shares, injecting
funds into the company. This vote of confidence, as well as Mr. Kersten's
belief that more government grants will follow, puts the company in an
excellent position to continue its important work.
The Right Direction
The company's stock has moved up-touching 24 cents last week --since our
last article in January
when the shares were under 20 cents. Following a convincing bounce off
the August 2002 low, the shares have been trading up nicely on decent volumes.
Technically, a break above 28 cents would confirm a new up-trend. Volumes
have also picked up recently, evidencing increasing interest in the shares
and the company.
CEL-SCI is a company that deserves
investor attention. The CEO, Geert Kersten, supplements the standard corporate
press releases with frequent updates from the executive suite in the form
of corporate, goal-oriented Letters to Shareholders. Mr. Kersten and his
team's focus and palpable excitement for CEL-SCI's work is infectious-no
pun intended.
Developing immune-based drugs and
therapies is on the cutting edge of biotech research and few companies
have made the commitment that CEL-SCI has to the discipline. For more than
a decade the company has moved forward, overcoming significant obstacles
including tough markets, a big pharma industry more interested in late-stage
therapies, and the constant need to acquire funding.
CEL-SCI has flourished in this challenging
environment and today's press release reveals yet another positive step
that will further validate both the research and investors' patience.
Your emailed thoughts, as always
are most welcome. Email us here: editor@smallcapnetwork.com
and give us your thoughts, ideas and comments.
Below is a copy of the press release
in its entirety for your review:
INVESTOR
Relations
Northeastern Ohio Universities
College of Medicine:
Lisa Lambert
(330) 325-6675
Investor Relations Group:
Lisa Lindberg
(212) 825-3210
NORTHEASTERN OHIO UNIVERSITIES COLLEGE
OF MEDICINE AND CEL-SCI SHARE $1.1 MILLION U.S. GOVERNMENT GRANT FOR DEVELOPMENT
OF CEL-1000 AGAINST VIRAL ENCEPHALITIS
VIENNA, VA, APRIL 4, 2003 --
NORTHEASTERN OHIO UNIVERSITIES COLLEGE OF MEDICINE (NEOUCOM) has been awarded
a $1.1 million grant for collaborative studies with CEL-SCI CORPORATION
(AMEX: CVM) to support the research of Ken S. Rosenthal, Ph.D. and
colleagues on the development of CEL-SCI's new compound, CEL-1000, as a
possible treatment for viral encephalitis. Viral encephalitis is
a potentially lethal inflammation of the brain.
More than 100 different types of
viruses can cause acute encephalitis. In the United States, the most
frequently reported causes are herpes simplex virus type 1 (HSV-1) and
type 2 (HSV-2) and viruses spread by insects. These include:
The West Nile Virus and three viruses that the U.S. government has included
in the second highest level immediate risk category for use as biological
weapons - The Venezuelan Equine Encephalitis (VEE), the Eastern Equine
Encephalitis (EEE) and Western Equine Encephalitis (WEE). Antiviral
drugs are available for the treatment of herpes simplex virus infections,
but antiviral drugs are not available for other encephalitis causing viruses.
Daniel Zimmerman, Senior Vice President
of Research, Cellular Immunology of CEL-SCI commented, "We believe that
there could be significant potential for CEL-1000 as a possible treatment
for viral encephalitis. Earlier studies in Dr. Rosenthal's lab with
Dr. Neena Goel had shown high levels of protection in animal studies against
Herpes Simplex Virus. Other researchers have shown that CEL-1000
also protects against malaria and cancer in animal models. These
studies suggest that CEL-1000 modulates the immune system to more effectively
fight different diseases."
This grant was awarded following
a peer review process and will fund pre-clinical studies leading up to
toxicology studies.
CEL-1000 is a modified version of
a human immune-based protein known to bind to both human and mouse immune
cells and appears to act by enhancing the host's immune protective immune
response. It is also expected to be active for humans.
CEL-SCI Corporation is developing
new immune system based treatments for cancer and infectious diseases.
The Company has operations in Vienna, Virginia and Baltimore, Maryland.
# # #
When used in this report, the words
"intends," "believes," "anticipated" and "expects" and similar expressions
are intended to identify forward-looking statements. Such statements
are subject to risks and uncertainties which could cause actual results
to differ materially from those projected. Factors that could cause
or contribute to such differences include, an inability to duplicate the
clinical results demonstrated in clinical studies, timely development of
any potential products that can be shown to be safe and effective, receiving
necessary regulatory approvals, difficulties in manufacturing any of the
Company's potential products, inability to raise the necessary capital
and the risk factors set forth from time to time in CEL-SCI Corporation's
SEC filings, including but not limited to its report on Form 10-K for the
year ended September 30, 2002. The Company undertakes no obligation
to publicly release the result of any revision to these forward-looking
statements which may be made to reflect the events or circumstances after
the date hereof or to reflect the occurrence of unanticipated events.
D I S C
L A I M E R :
The
SmallCap Digest is an independent electronic publication committed to providing
our readers with factual information on selected publicly traded
companies. SmallCap Digest is not a registered investment advisor or broker-dealer.
All companies are chosen on the basis of certain financial analysis and
other pertinent criteria with a view toward maximizing the upside
potential for investors while minimizing the downside risk, whenever possible.
Moreover, as detailed below, this publication accepts compensation from
third party consultants and/or companies which it features for the publication
and circulation of the SmallCap Digest or representation on SmallCapNetwork.net.
Likewise, this newsletter is owned by TGR, LLC. To the degrees enumerated
herein, this newsletter should not be regarded as an independent
publication.
Click
Here to view our compensation on every company we have ever covered,
or visit the following web address: http://access.smallcapnetwork.com/compensation_disclosure.html
for our full compensation disclosure and http://access.smallcapnetwork.com/short_term_alerts.html
for Trading Alerts compensation and disclosure. TGR Group, LLC has been
pledged a fee of $25,000 and 250,000 shares of newly issued restricted
stock of Cel-Sci for coverage of the company for a period of one year.
All statements
and expressions are the sole opinions of the editors and are subject
to change without notice. A profile, description, or other mention of a
company in the newsletter is neither an offer nor solicitation to buy or
sell any securities mentioned. While we believe all sources of information
to be factual and reliable, in no way do we represent or guarantee the
accuracy thereof, nor the statements made herein.
The editor,
members of the editor's family, and/or entities with which the editor
is affiliated, are forbidden by company policy to own, buy, sell or otherwise
trade stock for their own benefit in the companies who appear in the publication.
The profiles, critiques, and other editorial content of the SmallCap Digest
and SmallCapNetwork.net may contain forward-looking statements relating
to the expected capabilities of the companies mentioned herein.
THE READER
SHOULD VERIFY ALL CLAIMS AND DO THEIR OWN DUE DILIGENCE BEFORE INVESTING
IN ANY SECURITIES MENTIONED. INVESTING IN SECURITIES IS SPECULATIVE
AND CARRIES A HIGH DEGREE OF RISK. THE INFORMATION FOUND IN THIS PROFILE
IS PROTECTED BY THE COPYRIGHT LAWS OF THE UNITED STATES AND MAY NOT BE
COPIED, OR REPRODUCED IN ANY WAY WITHOUT THE EXPRESSED, WRITTEN CONSENT
OF THE EDITORS OF SMALLCAPNETWORK.NET.
We encourage
our readers to invest carefully and read the investor information available
at the web sites of the Securities and Exchange Commission ("SEC")
at http://www.sec.gov and/or the National
Association of Securities Dealers ("NASD") at http://www.nasd.com.
We also strongly recommend that you read the SEC advisory to investors
concerning Internet Stock Fraud, which can be found at http://www.sec.gov/consumer/cyberfr.htm
. Readers can review all public filings by companies at the SEC's EDGAR
page. The NASD has published information on how to invest carefully at
its web site.